兔抗Fadd(Phospho-Ser191) 多克隆抗體

Background:

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Applications:

WB, IHC

Name of antibody:

Fadd(Phospho-Ser191)

Immunogen:

Peptide sequence around phosphorylation site of Serine191(R-S-G(p)-A-M) derived from Human FADD.

Full name:

Fas (TNFRSF6)-associated via death domain

Synonyms：

GIG3; MORT1

SwissProt:

Q13158

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

23 kDa

WB Positive control:

Jurkat cells lysates treated with PMA

WB Recommended dilution:

500-1000